This post contains information regarding the use of animals for scientific discovery. If you would rather not read this, stop when you get to the “pre-clinical trial” section. This week we’ve been getting some amazing news about the fight against the pandemic. One was the clinical trial results of a “super vaccine” or pan-coronavirus (pan-CoV) vaccine: a variant proof COVID19 vaccine.
This is exciting information! Thank you. On another note, would love to hear more about long-covid and solutions on that front. While preventing death is top priority in a pandemic, I worry that we don't give post-viral disabilities the attention they deserve.
When are you going to discuss basic things that promote a robust immune system? It might also be informative to tell your readers about the disastrous dengue, hiv and RSV vaccines that have been tried because I’m sure they don’t know this history.
Hi, is there any correlation with elite neutralisers and long haulers ? I was bed ridden after my second pfizer-biontech vax for two months. During my initial infection I only took two weeks off work. This seems quite rare and many long haulers have had adverse reactions to the vaccine. It is very hard to get T-cell or B-cell tests done for non-researchers. Would love to hear your thoughts.
Super interesting. I suppose they could even include some function-gain engineered spikes to help prevent against future mutations?
FWIW, currently augmenting my immunity the hard way. Have break through case. Most likely Omicron. Day 4 of symptoms, day 2 of positive test. So far, symptoms like a cold that can't quite get it's act together. Hope it stays that way.
Wow! This just gives me goosebumps. Dr. Jetelina, you have been one of the strongest factors helping me maintain my sanity and hope during this pandemic.
Also, the Army vaccine as tested only has one type of spike affixed. It also contains the lovely adjuvant "ALFQ". Sorry, no, I won't roll up my sleeve.
The Army - Water Reed soccerball will have the (modified) spikes from currently circulating variants. We have seen what evolutionary pressure applied from just three (modified) spike variants can do, imagine the variants that will escape that!
I'm a new subscriber. Thank you for this wealth of information. I am looking for guidance regarding what is being recommended for people who experienced severe neurological allergic reactions within 30 days of receiving their first vaccine. That was my experience after a Pfizer vaccine March 2021. My reactions lasted 5 weeks. I submitted a VAERS report to the CDC. I haven't taken a second vaccine. Nothing has been found after a complete blood panel during symptoms, a brain MRI, several appts. with my PCP, a Neurologist and and an Immunologist. I've been researching on my own. I would GREATLY appreciate any information you could provide or recommendation as to who I can contact for help!!
While these data are provocative they are based on a platform that will take time to build and thoroughly test while the virus evolves. I am more intrigued by increasing our understanding of enhanced immunity experienced in those with 1. natural infection followed by full vaccination /boosting and 2. even more interesting is understanding what immunity to evolving variants in the massively growing population of fully vaxed followed by breakthrough (mostly delta until now) Double breakthrough is exceedingly uncommon clinically (thus far) and we need to understand why and hopefully how mild subclinical breakthrough may add formidably to the concept of true herd immunity which so far has been elusive with standard vaccine alone.
Can we assume that phase 2 and 3 trials will have to include people who've already received the existing COVID 19 vaccines to evaluate the safety of "mixing" the pan corona vaccine with the other vaccines received? Or will this new vaccine only be tested on unvaccinated individuals and we'll have to wait even longer to find out if the rest of us will be eligible?
Thank you for your informative and hopeful email. I hope that it will be more available than existing vaccines too. It would not be good to have some super immune and some not at all, because they couldn't pay for it.
This is exciting information! Thank you. On another note, would love to hear more about long-covid and solutions on that front. While preventing death is top priority in a pandemic, I worry that we don't give post-viral disabilities the attention they deserve.
When are you going to discuss basic things that promote a robust immune system? It might also be informative to tell your readers about the disastrous dengue, hiv and RSV vaccines that have been tried because I’m sure they don’t know this history.
Epidemiology question:
Is it essentially correct (in terms of evolution) that if *we can’t* eliminate this virus that we want one that is:
A) As highly transmissible as possible
B) As benign as possible
Wouldn’t this be best for the virus and for us? Please excuse me if I’m missing something rudimentary
Hi, is there any correlation with elite neutralisers and long haulers ? I was bed ridden after my second pfizer-biontech vax for two months. During my initial infection I only took two weeks off work. This seems quite rare and many long haulers have had adverse reactions to the vaccine. It is very hard to get T-cell or B-cell tests done for non-researchers. Would love to hear your thoughts.
So... one syRINGe to rule them all?
Super interesting. I suppose they could even include some function-gain engineered spikes to help prevent against future mutations?
FWIW, currently augmenting my immunity the hard way. Have break through case. Most likely Omicron. Day 4 of symptoms, day 2 of positive test. So far, symptoms like a cold that can't quite get it's act together. Hope it stays that way.
Wow! This just gives me goosebumps. Dr. Jetelina, you have been one of the strongest factors helping me maintain my sanity and hope during this pandemic.
Also, the Army vaccine as tested only has one type of spike affixed. It also contains the lovely adjuvant "ALFQ". Sorry, no, I won't roll up my sleeve.
Going to have to disagree with "The difference for SARS-CoV-2 is that it mutates far less than HIV or influenza", have a look at this:
https://nextstrain.org/ncov/gisaid/global
The Army - Water Reed soccerball will have the (modified) spikes from currently circulating variants. We have seen what evolutionary pressure applied from just three (modified) spike variants can do, imagine the variants that will escape that!
I'm a new subscriber. Thank you for this wealth of information. I am looking for guidance regarding what is being recommended for people who experienced severe neurological allergic reactions within 30 days of receiving their first vaccine. That was my experience after a Pfizer vaccine March 2021. My reactions lasted 5 weeks. I submitted a VAERS report to the CDC. I haven't taken a second vaccine. Nothing has been found after a complete blood panel during symptoms, a brain MRI, several appts. with my PCP, a Neurologist and and an Immunologist. I've been researching on my own. I would GREATLY appreciate any information you could provide or recommendation as to who I can contact for help!!
While these data are provocative they are based on a platform that will take time to build and thoroughly test while the virus evolves. I am more intrigued by increasing our understanding of enhanced immunity experienced in those with 1. natural infection followed by full vaccination /boosting and 2. even more interesting is understanding what immunity to evolving variants in the massively growing population of fully vaxed followed by breakthrough (mostly delta until now) Double breakthrough is exceedingly uncommon clinically (thus far) and we need to understand why and hopefully how mild subclinical breakthrough may add formidably to the concept of true herd immunity which so far has been elusive with standard vaccine alone.
Intriguing work by
Michel Nussinszweig
Lin-Fa Wang
others
Thank you for explaining this exciting news. It has given me much-needed hope.
Clear, concise description of some fascinating biology, I’m now looking forward to more results in the near future-Thank you! 🙏😺
Can we assume that phase 2 and 3 trials will have to include people who've already received the existing COVID 19 vaccines to evaluate the safety of "mixing" the pan corona vaccine with the other vaccines received? Or will this new vaccine only be tested on unvaccinated individuals and we'll have to wait even longer to find out if the rest of us will be eligible?
Wow!
Thank you for your informative and hopeful email. I hope that it will be more available than existing vaccines too. It would not be good to have some super immune and some not at all, because they couldn't pay for it.
Wishing everyone a safe and happy holiday season.