26 Comments
founding

This is exciting information! Thank you. On another note, would love to hear more about long-covid and solutions on that front. While preventing death is top priority in a pandemic, I worry that we don't give post-viral disabilities the attention they deserve.

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When are you going to discuss basic things that promote a robust immune system? It might also be informative to tell your readers about the disastrous dengue, hiv and RSV vaccines that have been tried because I’m sure they don’t know this history.

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All medicine has risk. The idea is to weigh the risk of treatment versus the risk of disease to the individual and the population. You seem "sure" that people don't understand things, but your commentary seems to indicate you have an opinion you want to push. This isn't the place for that.

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Dec 27, 2021·edited Dec 27, 2021

Epidemiology question:

Is it essentially correct (in terms of evolution) that if *we can’t* eliminate this virus that we want one that is:

A) As highly transmissible as possible

B) As benign as possible

Wouldn’t this be best for the virus and for us? Please excuse me if I’m missing something rudimentary

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Hi, is there any correlation with elite neutralisers and long haulers ? I was bed ridden after my second pfizer-biontech vax for two months. During my initial infection I only took two weeks off work. This seems quite rare and many long haulers have had adverse reactions to the vaccine. It is very hard to get T-cell or B-cell tests done for non-researchers. Would love to hear your thoughts.

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Dec 29, 2021·edited Dec 29, 2021

So... one syRINGe to rule them all?

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Super interesting. I suppose they could even include some function-gain engineered spikes to help prevent against future mutations?

FWIW, currently augmenting my immunity the hard way. Have break through case. Most likely Omicron. Day 4 of symptoms, day 2 of positive test. So far, symptoms like a cold that can't quite get it's act together. Hope it stays that way.

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founding

Wow! This just gives me goosebumps. Dr. Jetelina, you have been one of the strongest factors helping me maintain my sanity and hope during this pandemic.

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Also, the Army vaccine as tested only has one type of spike affixed. It also contains the lovely adjuvant "ALFQ". Sorry, no, I won't roll up my sleeve.

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Since you feel so strongly against this component, would you like to share a reputable source describing your concerns?

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I am a reputable source. My concern is I have found no prior published safety data on any vaccine containing it given to humans, only Rhesus macaques. Nor can I find any information about it's MOA, similar to the aluminum containing adjuvants, no one is quite sure how they work. I do not trust anything that just magically works to not be harmful.

"However, how these mineral agents influence the immune response to vaccination remains elusive. Many hypotheses exist as to the mode of action of these adjuvants"

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4406982/

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founding

Your unsubstantiated and vague concerns are common, but they don't make anyone a "reputable source". Since you're making the claim, the onus is on you to provide links to peer-reviewed research that actually supports your hypothesis that aluminum-containing adjuvants, or adjuvants similar to them, are indeed harmful. The insistence that vaccine adjuvants cause illness is one of the major scare tactics employed by those who are against vaccines in general.

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Not knowing the MOA is not a vague concern nor is it unsubstantiated.

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Not posting your references, however, is.

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Like Sadam Hussain told gwb, how can i prove i don't have something

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Going to have to disagree with "The difference for SARS-CoV-2 is that it mutates far less than HIV or influenza", have a look at this:

https://nextstrain.org/ncov/gisaid/global

The Army - Water Reed soccerball will have the (modified) spikes from currently circulating variants. We have seen what evolutionary pressure applied from just three (modified) spike variants can do, imagine the variants that will escape that!

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I'm a new subscriber. Thank you for this wealth of information. I am looking for guidance regarding what is being recommended for people who experienced severe neurological allergic reactions within 30 days of receiving their first vaccine. That was my experience after a Pfizer vaccine March 2021. My reactions lasted 5 weeks. I submitted a VAERS report to the CDC. I haven't taken a second vaccine. Nothing has been found after a complete blood panel during symptoms, a brain MRI, several appts. with my PCP, a Neurologist and and an Immunologist. I've been researching on my own. I would GREATLY appreciate any information you could provide or recommendation as to who I can contact for help!!

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While these data are provocative they are based on a platform that will take time to build and thoroughly test while the virus evolves. I am more intrigued by increasing our understanding of enhanced immunity experienced in those with 1. natural infection followed by full vaccination /boosting and 2. even more interesting is understanding what immunity to evolving variants in the massively growing population of fully vaxed followed by breakthrough (mostly delta until now) Double breakthrough is exceedingly uncommon clinically (thus far) and we need to understand why and hopefully how mild subclinical breakthrough may add formidably to the concept of true herd immunity which so far has been elusive with standard vaccine alone.

Intriguing work by

Michel Nussinszweig

Lin-Fa Wang

others

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Thank you for explaining this exciting news. It has given me much-needed hope.

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Clear, concise description of some fascinating biology, I’m now looking forward to more results in the near future-Thank you! 🙏😺

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founding

Can we assume that phase 2 and 3 trials will have to include people who've already received the existing COVID 19 vaccines to evaluate the safety of "mixing" the pan corona vaccine with the other vaccines received? Or will this new vaccine only be tested on unvaccinated individuals and we'll have to wait even longer to find out if the rest of us will be eligible?

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Ideally, at least the Phase 2 trials would be in "pristine" adults. That was a drawback of the Phase 1 trials, and having to wait to get sufficient untainted subjects. I suspect the Phase 2 application will include a subset of previously vaccinated subjects to evaluate safety/efficacy and the Phase 3 trial will allow them, but this is conjecture on my part.

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Thank you for your informative and hopeful email. I hope that it will be more available than existing vaccines too. It would not be good to have some super immune and some not at all, because they couldn't pay for it.

Wishing everyone a safe and happy holiday season.

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