With the possible exception of the ionophore argument virtually all the other potential pathways are no longer considered viable, to the best of my knowledge and prior reading. I'll reserve judgement about the ionphore argument at this time. One of the issues with ivermectin was that, in order to effect any in silico action, concentrations were required to be so high that CNS toxicity would likely be noted in vitro. The levels required to affect parasites are much lower than those apparently required to create significant antiviral effects through any of the pathways indicated by Zaidi and Deghani.
This was at the beginning…and lots of speculation. https://www.nature.com/articles/s41429-021-00491-6
With the possible exception of the ionophore argument virtually all the other potential pathways are no longer considered viable, to the best of my knowledge and prior reading. I'll reserve judgement about the ionphore argument at this time. One of the issues with ivermectin was that, in order to effect any in silico action, concentrations were required to be so high that CNS toxicity would likely be noted in vitro. The levels required to affect parasites are much lower than those apparently required to create significant antiviral effects through any of the pathways indicated by Zaidi and Deghani.
Thank you, however, for providing the reference.
Looking now, thanks.