As epidemiologists, “primary prevention” is our main goal—reduce morbidity and mortality by preventing large populations from getting disease altogether. Vaccines are our best (but not only) tool to prevent severe disease from SARS-CoV-2. But even if someone gets the vaccine, there is still a small chance they could end up in the hospital. (This is
The independent study cited of Paxlavoid was *in vitro* so my question about whether folks have 5 days to start it, as was the case for Delta, or fewer, because of Omicron’s shorter infectivity timeframe, remains unexplored.
Please comment on the drug-drug interactions with Paxlovid, it seems as though those at greatest risk for death are also taking some very common drugs for which Paxlovid might lead to significant toxicity. Were patients taking those drugs excluded from the trial?
I think I'd take a pass on Molnupiravir. But I'm fretting a lot about the testing situation for people wanting and needing Paxlovid . You have to be diagnosed with covid to get it, right?
But it's currently extremely hard to get a test. So the testing situation's a bottleneck.
Is there any information - data, or information speculation - of Paxlovid's potential for reducing Long Covid ?
Specifically, do we now know whether Long Covid is correlated with disease-severity and/or viral-load (and thus Paxlovid's action towards reducing viral load would likely also act to reduce chances of Long Covid) ?
To all the commenters who tend to suggest there's some hidden cabal behind vaccines, please take note of the "Possible dangers" paragraph. This is called actual science.
Another excellent presentation of the data. I really appreciate that you focus on the data and minimally interpret it. It's important for people to understand that unambiguous answers take time, and leaping to conclusions based on preliminary results can be misleading.
Coronaviruses, unlike most RNA viruses, have a "spell checker" function, to detect copy errors. This is a challenge for antiviral drugs that scramble the copying mechanism, like remdesivir, molnupiravir and others in that class.
Thanks doc, hope you and yours are feeling better. Happy New Year!
Here's hoping for 2022, and Cobrevax: give.texaschildrens.org. I am Irish; I am very grateful for what the US has been able to do to get a leash on the pandemic. If I were American, I would be very proud.
More great info...
FYI - i was had covid - was double vaccinated - just finished omicron.. 2 days mild symptoms, all better now.
Previous COVID didn't help nor did 2 shots . The concept of super immunity can be put to rest... now i have 2 bouts of COVID - 2 shots.
Happy Healthy New Year to all!!!! 2022 will be an amazing year for us all.
Thank you for all you do, Katelyn!
The independent study cited of Paxlavoid was *in vitro* so my question about whether folks have 5 days to start it, as was the case for Delta, or fewer, because of Omicron’s shorter infectivity timeframe, remains unexplored.
We are getting so well educated! Thank you.
Thanks once again for this great analysis. I suspect I would refuse Molnupiravir if it were offered. I
am also surprised that drug was authorized.
Please comment on the drug-drug interactions with Paxlovid, it seems as though those at greatest risk for death are also taking some very common drugs for which Paxlovid might lead to significant toxicity. Were patients taking those drugs excluded from the trial?
Richard Stevenart (see below) is a troll. Who would care to pitch in on a gift to our local epidemiologist so that he might be banned?
I got $20 on it.
I think I'd take a pass on Molnupiravir. But I'm fretting a lot about the testing situation for people wanting and needing Paxlovid . You have to be diagnosed with covid to get it, right?
But it's currently extremely hard to get a test. So the testing situation's a bottleneck.
Is there any information - data, or information speculation - of Paxlovid's potential for reducing Long Covid ?
Specifically, do we now know whether Long Covid is correlated with disease-severity and/or viral-load (and thus Paxlovid's action towards reducing viral load would likely also act to reduce chances of Long Covid) ?
To all the commenters who tend to suggest there's some hidden cabal behind vaccines, please take note of the "Possible dangers" paragraph. This is called actual science.
Btw, you assume a lot. I have an IQ of 142 and hold three patents. Talk some more smack.
Another excellent presentation of the data. I really appreciate that you focus on the data and minimally interpret it. It's important for people to understand that unambiguous answers take time, and leaping to conclusions based on preliminary results can be misleading.
Coronaviruses, unlike most RNA viruses, have a "spell checker" function, to detect copy errors. This is a challenge for antiviral drugs that scramble the copying mechanism, like remdesivir, molnupiravir and others in that class.
Hope your family is recovering nicely from covid.
Looks like once we get by the Omicron tsunami we might be able to have a mostly normal 2022.
Thanks doc, hope you and yours are feeling better. Happy New Year!
Here's hoping for 2022, and Cobrevax: give.texaschildrens.org. I am Irish; I am very grateful for what the US has been able to do to get a leash on the pandemic. If I were American, I would be very proud.
Is there any thought on outdoor transmission with omicron? Thanks! hope your family is doing well.
Any informatoin on whether Paxlovid would lessen the time someone is infectious?