Five billion dollars was just allocated to Operation Next Gen with one goal: speed the creation of next-generation COVID-19 vaccines and therapies, including nasal (mucosal) vaccines. I advocated for this at the White House, but it’s going to be a hard road. Here’s why.
SaNoTize is a measured nitric oxide spray application that has been clinically proven to kill all viruses in the nose. It was originally developed as a prophylactic against the flu. The tests showed that It kills ALL covid 19 virus in the nose within two minutes, and reduces viral load to a nearly undetectable amount in infected patients after two days. But don't take my word for it. Here is the result of the third stage trials in the LANCET. I use Enovid (its name in Israel) and it appears to work. I have traveled, gone to crowded venues with poor ventilation, (although I still wear a mask) and eaten in restaurants, with no infection. There are no contraindications with any medication.. It is not a drug. Nevertheless The CDC and Health Canada have not authorized it. Israel, Germany, India and Singapore DID in 2021, and it's available in any drugstore in those countries. The additional tests by Health Canada and CDC should be expedited. It's even more inexcusable in Canada, since it was developed in Vancouver. https://www.thelancet.com/journals/lansea/article/PIIS2772-3682(22)00046-4/fulltext
SaNoTize are developing a nasal flu vaccine. They should receive funding.
I also came to the comments today to share my experience with anti-viral nose sprays. I've been hoping for a post on these, but as mentioned by another commenter - they seem to risk falling into the 'misinformation' camp and so aren't talked about by many responsible COVID communicators. I have been using both Enovid and an iota-carrageenan spray for about a year now with good success. I am teacher in a primary school as is my husband and our two children attend the same school - so we have quite a bit of exposure!! During the winter and times of heavy transmission we all used the iota-carrageenan spray before school and Enovid after school. They both some decent studies with anti-viral success and seemed worth the try. We did not mask this year (though I do when working with actively sick kids and colleagues which happens a lot). We were sick significantly less than other students and staff. We also have travelled successfully (masking in airports/planes but not much elsewhere). We also managed one COVID case (picked up from a haircut in which my son forgot nose spray) without the rest of us getting sick (we did all use high-quality masks, lots of fresh air and isolation in addition to lots of nose spray).
For those in the EU, Enovid is now available through MaskWholesale.eu and is only 20 euros per bottle (still pricey but better than straight from the Sanotize website).
I really appreciate Dr. Jetelina’s and her colleague’s clear, fair-minded explanations. For me, this article is particularly helpful so as to have appropriate expectations: could be promising, but no magic bullet coming soon. This is just what I hope for and always get from Dr.Jetelina: clear, honest information, warts and all.
I see the discussion that has ensued here re Sanotize, all of which is new to me, and would be interested in any insight Dr. Jetelina and or her colleague can offer on that, as well.
Great article. All the potential challenges and pitfalls notwithstanding, I wonder if any researchers are going to try simultaneous IM and Nasal vaccination? Might this spark an immune response like sending in the army and navy?
Nicely done, as usual. Seems like something to really fund as benefits beyond Covid, and possibly unexpected, will likely result.
But why not target a more stable part of the virus? Why couldn’t a good pan corona vaccine essentially do what the mucosal is intended to do, either by dampening (if possible) transmission or by making infection useless, at least to the virus, from an evolutionary perspective. As in: “Change all ya like—it’ll do ya no good, as biophysics prevents you from changing this bit of structural whatnot we targeted.”
My dermatologist told me about Enovid, she buys it from the Israeli pharmacy online. Her family uses it. I’m not sure about the effectiveness of it, but it’s likely not harmful. Just expensive. A family member has started to use it.
This website contains information about products that may not be available in all countries, or may be available under different trademarks, for different indications, or in different dosages. Nothing contained herein should be considered a solicitation, promotion or advertisement for any drug or medical device including the ones under development on this web site.
Any information on the products contained herein is not intended to provide medical advice nor should be used as a substitute for the advice provided by your physician or other healthcare provider.
Prime and Pull - has this been studied in the opposite direction - intranasal vaccine followed by parenteral booster? Intuitively, I would think this wouldn't work as well, but curious if it has actually been studied.
SaNoTize is a measured nitric oxide spray application that has been clinically proven to kill all viruses in the nose. It was originally developed as a prophylactic against the flu. The tests showed that It kills ALL covid 19 virus in the nose within two minutes, and reduces viral load to a nearly undetectable amount in infected patients after two days. But don't take my word for it. Here is the result of the third stage trials in the LANCET. I use Enovid (its name in Israel) and it appears to work. I have traveled, gone to crowded venues with poor ventilation, (although I still wear a mask) and eaten in restaurants, with no infection. There are no contraindications with any medication.. It is not a drug. Nevertheless The CDC and Health Canada have not authorized it. Israel, Germany, India and Singapore DID in 2021, and it's available in any drugstore in those countries. The additional tests by Health Canada and CDC should be expedited. It's even more inexcusable in Canada, since it was developed in Vancouver. https://www.thelancet.com/journals/lansea/article/PIIS2772-3682(22)00046-4/fulltext
SaNoTize are developing a nasal flu vaccine. They should receive funding.
I also came to the comments today to share my experience with anti-viral nose sprays. I've been hoping for a post on these, but as mentioned by another commenter - they seem to risk falling into the 'misinformation' camp and so aren't talked about by many responsible COVID communicators. I have been using both Enovid and an iota-carrageenan spray for about a year now with good success. I am teacher in a primary school as is my husband and our two children attend the same school - so we have quite a bit of exposure!! During the winter and times of heavy transmission we all used the iota-carrageenan spray before school and Enovid after school. They both some decent studies with anti-viral success and seemed worth the try. We did not mask this year (though I do when working with actively sick kids and colleagues which happens a lot). We were sick significantly less than other students and staff. We also have travelled successfully (masking in airports/planes but not much elsewhere). We also managed one COVID case (picked up from a haircut in which my son forgot nose spray) without the rest of us getting sick (we did all use high-quality masks, lots of fresh air and isolation in addition to lots of nose spray).
For those in the EU, Enovid is now available through MaskWholesale.eu and is only 20 euros per bottle (still pricey but better than straight from the Sanotize website).
While it isn’t a vaccine what do you think of Israel’s enovid as a precautionary measure?
I really appreciate Dr. Jetelina’s and her colleague’s clear, fair-minded explanations. For me, this article is particularly helpful so as to have appropriate expectations: could be promising, but no magic bullet coming soon. This is just what I hope for and always get from Dr.Jetelina: clear, honest information, warts and all.
I see the discussion that has ensued here re Sanotize, all of which is new to me, and would be interested in any insight Dr. Jetelina and or her colleague can offer on that, as well.
Novavax may elicit mucosal immunity after 3rd shot- not sure why that isn’t discussed more often:
https://donford.substack.com/p/the-benefits-of-novavax-explained
I have two questions:
Does a nasal vaccine also protect mucosal membranes in the throat, in case COVID is breathed in through mouth?
If a nasal vaccine is a live virus, can someone who is just vaccinated infect another person?
Great article. All the potential challenges and pitfalls notwithstanding, I wonder if any researchers are going to try simultaneous IM and Nasal vaccination? Might this spark an immune response like sending in the army and navy?
Some precedent for this upon quick search:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7812058/
Nicely done, as usual. Seems like something to really fund as benefits beyond Covid, and possibly unexpected, will likely result.
But why not target a more stable part of the virus? Why couldn’t a good pan corona vaccine essentially do what the mucosal is intended to do, either by dampening (if possible) transmission or by making infection useless, at least to the virus, from an evolutionary perspective. As in: “Change all ya like—it’ll do ya no good, as biophysics prevents you from changing this bit of structural whatnot we targeted.”
Let’s fund both/all!
Excellent material - Thank you
Thanks to all who comment. You provide me with ideas and opinions which I so much appreciate.
My dermatologist told me about Enovid, she buys it from the Israeli pharmacy online. Her family uses it. I’m not sure about the effectiveness of it, but it’s likely not harmful. Just expensive. A family member has started to use it.
Thank you for mentioning the Pan-coronavirus “super” vaccine at the bottom of this article; I had completely missed that one. Fascinating stuff!
Just got my 65+ extra injection! The pharmacist referred to it as a "booster," but I said I preferred to think of it as a "Big Boy's shot." :)
So I asked Microsoft Bing 'how to purchase SaNotize'.
There are numerous options and sources. Prices range between $170 and $250.
=======
Of interest is the pop-up on the site https://sanotize.com/faq/ that states:
IMPORTANT NOTICE
This website contains information about products that may not be available in all countries, or may be available under different trademarks, for different indications, or in different dosages. Nothing contained herein should be considered a solicitation, promotion or advertisement for any drug or medical device including the ones under development on this web site.
Any information on the products contained herein is not intended to provide medical advice nor should be used as a substitute for the advice provided by your physician or other healthcare provider.
======
There is some promotional/sales info here:
https://www.israelpharm.com/blog/newsweek-asks-why-the-fda-is-refusing-to-allow-use-of-nasal-sprays-as-a-barrier-against-covid-19/
There was early research suggesting that using a steroid nasal spray reduced covid infection and symptoms. Any updates on that?
#6 - For live attenuated replication competent virus vaccines, there are two additional issues:
1. Risk/benefit at the individual level - depending on your circumstances deliberately exposing yourself to a pathogen may not be worth it
2. Risk/benefit at the population level - a live attenuated virus could mutate to something more virulent
Prime and Pull - has this been studied in the opposite direction - intranasal vaccine followed by parenteral booster? Intuitively, I would think this wouldn't work as well, but curious if it has actually been studied.