Five billion dollars was just allocated to Operation Next Gen with one goal: speed the creation of next-generation COVID-19 vaccines and therapies, including nasal (mucosal) vaccines. I advocated for this at the White House, but it’s going to be a hard road.
SaNoTize is a measured nitric oxide spray application that has been clinically proven to kill all viruses in the nose. It was originally developed as a prophylactic against the flu. The tests showed that It kills ALL covid 19 virus in the nose within two minutes, and reduces viral load to a nearly undetectable amount in infected patients after two days. But don't take my word for it. Here is the result of the third stage trials in the LANCET. I use Enovid (its name in Israel) and it appears to work. I have traveled, gone to crowded venues with poor ventilation, (although I still wear a mask) and eaten in restaurants, with no infection. There are no contraindications with any medication.. It is not a drug. Nevertheless The CDC and Health Canada have not authorized it. Israel, Germany, India and Singapore DID in 2021, and it's available in any drugstore in those countries. The additional tests by Health Canada and CDC should be expedited. It's even more inexcusable in Canada, since it was developed in Vancouver. https://www.thelancet.com/journals/lansea/article/PIIS2772-3682(22)00046-4/fulltext
SaNoTize are developing a nasal flu vaccine. They should receive funding.
My doctor recommended SaNoTize to me. I have used it for the last 6 months before and after any indoor activity (flight, haircut - still mask). When it comes to seeing friends or dining at restaurants, I opt for outdoors. So far, so good. (I’m also vaxed and boosted).
My husband (also vaxed and boosted) had Covid in May ‘22. I could not have been more exposed to him before he tested positive. I did get a funky sore throat (with lots of “raw egg white” saliva) but gargled aggressively with warm salt water 3x per day. I never tested positive (including 2 PCRs) despite my weird sore throat.
Did the salt water gargle prevent me from getting full blown covid? I have no idea. I’m also a swimmer (normal-high vitamin D, chlorine neti pot flip turns). I take a multi, vitamin C, zinc. Am I just following a bunch of quack witchcraft? Maybe. But at least I feel like I’m doing something.
Point is - it would be nice if we had a basic handle on some over-the-counter (SaNoTize) or home remedies that might prevent infection and/or lessen severity. The current vaccines aren’t enough! The FDA/CDC is reluctant to recommend anything additive because they fear it might cause one person not to vaccinate. Their only advice is “vaccine, vaccine, vaccine.” As a result, Americans are denied other reasonable options which could supplement vaccines. And Americans are increasingly saying “no, enough!” to the vaccine.
SaNoTize is not cheap. You can order it online and have it shipped from Israel. If enough Americans start importing it, the FDA will probably clamp down and prohibit it.
I had covid 19 in July 2022 and wish that i knew about Enovid at that time. It is a lot cheaper than getting sick and it probably costs pennies to make. Nitric oxide is the same substance given to premature babies, to kill viruses...it's not a novel substance; it's the spray bottle with the measured dose that makes it unique. There is no excuse not to approve it.
"The FDA/CDC is reluctant to recommend anything additive because they fear it might cause one person not to vaccinate. Their only advice is “vaccine, vaccine, vaccine.” This is not true.
"The FDA/CDC is reluctant to recommend anything additive because they fear it might cause one person not to vaccinate. Their only advice is “vaccine, vaccine, vaccine.” This is absolutely true! And it is a major problem.
They are also clearly more concerned about being blamed for any adverse results, than with taking that risk of blame to bring about the highly likely greater good of so many millions. That is never better illustrated than by the extended debate over the decision to ALLOW (not recommend) a six month vaccine for the elderly. That was a “no-brainer” but it invoked serious debate which shows the nature of the underlying predilections of the authorities. And the evidence would support an even more frequent vaccination for the elderly (50 million plus of us in the US). The only even mildly concerning hypothesis that would stand against more frequent vaxxing for seniors is the worry about OAS - a theory with very limited research and contradictory outcomes. But that fear of “safety” (however small the risk) - which dominates FDA and CDC decisions - is clearly what drives the thinking at those organizations. Never mind those of us at most risk of severe disease and death.
I believe the most likely reason you didn't test positive is that you're female. I've noticed this pattern with most discordant male/female couples I know, where the male is the index case.
Actually, it IS a drug. It's also a treatment, not a vaccine. The study looks promising, but only reports data for seven days
A/O last October the NIH was soliciting volunteers for a clinical trial of SaNoTize in the USA. Given that the sponsor is also the manufacturer (as was the case for the Lancet study), some skepticism may be justified. But we'll see. If this proves effective, it looks like it could be a useful treatment, but treatments are substitutes for prophylactic measures, of course.
I wear masks in addition to taking the Enovid, and I have two bivalent vaccinations...but I was too scared to go to social gatherings or restaurants until I got the spray. Health Canada started its trials in July 2022, just after the Lancet report. I believe this works, and I have seen it work for a relative and a friend who both improved greatly after I sent them some of my very limited stock. That is enough proof for me.
When I read today’s YLE, my first thought was: SaNoTize!
My second thought was: You can’t post anything about a nasal spray that’s not approved by the FDA, because that’s MISINFORMATION.
But then I saw others had already posted about SaNoTize and joined them.
Yes, it’s mind boggling more research isn’t being done. People have a hunger for more tools to counter the virus, which can quickly land them in misinformation quicksand, even if the tool in fact works.
"You can’t post anything about a nasal spray that’s not approved by the FDA, because that’s MISINFORMATION." Rubbish. You just proved it's rubbish, in fact. You can post anything you want.
Having what you post treated seriously, on the other hand, is another story. Maybe it you did the necessary work to provide credible evidence for the things you post, they'd be treated with more respect.
Yes, and I am desperate to try anything that “might” work. I am reading more on SaNotize and might order. It is a shame that it will be cost prohibitive for many.
I pay the price. It costs 50 per cent less in Germany, but the Israeli firm is willing to ship worldwide. It's particularly galling because the scientist who invented it is Canadian/Israeli, and she went to Israel to manufacture it because she knew that it would take too long to get manufacturing up and running here. What happened to Canada?
To the best of my knowledge, I’ve never had Covid despite being exposed more than once. About 5 years ago, before the pandemic, I had two shingles shots and one MMR (I had such a such a strong reaction to MMR that I never went back for shot 2 - high fever for 3 days and nonstop sleep 14 days after shot).
Are the shingles and MMR vaccines from 5 years ago protecting me from covid? Maybe, but nobody seems to be studying this.
I also came to the comments today to share my experience with anti-viral nose sprays. I've been hoping for a post on these, but as mentioned by another commenter - they seem to risk falling into the 'misinformation' camp and so aren't talked about by many responsible COVID communicators. I have been using both Enovid and an iota-carrageenan spray for about a year now with good success. I am teacher in a primary school as is my husband and our two children attend the same school - so we have quite a bit of exposure!! During the winter and times of heavy transmission we all used the iota-carrageenan spray before school and Enovid after school. They both some decent studies with anti-viral success and seemed worth the try. We did not mask this year (though I do when working with actively sick kids and colleagues which happens a lot). We were sick significantly less than other students and staff. We also have travelled successfully (masking in airports/planes but not much elsewhere). We also managed one COVID case (picked up from a haircut in which my son forgot nose spray) without the rest of us getting sick (we did all use high-quality masks, lots of fresh air and isolation in addition to lots of nose spray).
For those in the EU, Enovid is now available through MaskWholesale.eu and is only 20 euros per bottle (still pricey but better than straight from the Sanotize website).
I think these need to be discussed more. What spray do you use? I have been using Xlear with my children. The company got into trouble for touting benefits of preventing Covid, but that does not surprise me.
It makes me a lot more confident when traveling, it appears to work for others (a relative and friend both benefited from it when very ill) and in my case, there was an extremely beneficial unintended side effect . It does what they say it does.
I really appreciate Dr. Jetelina’s and her colleague’s clear, fair-minded explanations. For me, this article is particularly helpful so as to have appropriate expectations: could be promising, but no magic bullet coming soon. This is just what I hope for and always get from Dr.Jetelina: clear, honest information, warts and all.
I see the discussion that has ensued here re Sanotize, all of which is new to me, and would be interested in any insight Dr. Jetelina and or her colleague can offer on that, as well.
The nasal vaccine does not protect you from anything that gets in via the mouth. I had a small stomach virus after I started taking Enovid regularly. Fortunately it was short lived, but I used Tums to cure it.
Great article. All the potential challenges and pitfalls notwithstanding, I wonder if any researchers are going to try simultaneous IM and Nasal vaccination? Might this spark an immune response like sending in the army and navy?
Nicely done, as usual. Seems like something to really fund as benefits beyond Covid, and possibly unexpected, will likely result.
But why not target a more stable part of the virus? Why couldn’t a good pan corona vaccine essentially do what the mucosal is intended to do, either by dampening (if possible) transmission or by making infection useless, at least to the virus, from an evolutionary perspective. As in: “Change all ya like—it’ll do ya no good, as biophysics prevents you from changing this bit of structural whatnot we targeted.”
My dermatologist told me about Enovid, she buys it from the Israeli pharmacy online. Her family uses it. I’m not sure about the effectiveness of it, but it’s likely not harmful. Just expensive. A family member has started to use it.
This website contains information about products that may not be available in all countries, or may be available under different trademarks, for different indications, or in different dosages. Nothing contained herein should be considered a solicitation, promotion or advertisement for any drug or medical device including the ones under development on this web site.
Any information on the products contained herein is not intended to provide medical advice nor should be used as a substitute for the advice provided by your physician or other healthcare provider.
The bottom link takes you to an article with a “Buy Enovid” link at the very bottom. The button appears to still work. If you’re willing to buy 10 nasal sprays, the price drops to $40 per bottle. Not a bargain, but cheaper than flying to Germany, Israel or India to stock up.
The article is worth a read - thanks for posting it. If officials encourage us to use hand sanitizer for our hands, why can’t we have a sanitizer for our nose?
Why can’t these types of tools be viewed as supplements to the vaccine, instead of as threats?
I agree. I had very reactogenic experiences after my second and third Moderna and can get no medical guidance on how to handle future vaccines other than “get the booster.” I have not received any other Covid vaccines because my experiences were so terrifying. So, I am trying anything and everything that seems low risk/high benefit. I cannot understand why they are not exploring less reactogenic vaccines, non MRNA options, other means of protection. It seems very black and white when there’s actually a lot of gray.
Prime and Pull - has this been studied in the opposite direction - intranasal vaccine followed by parenteral booster? Intuitively, I would think this wouldn't work as well, but curious if it has actually been studied.
SaNoTize is a measured nitric oxide spray application that has been clinically proven to kill all viruses in the nose. It was originally developed as a prophylactic against the flu. The tests showed that It kills ALL covid 19 virus in the nose within two minutes, and reduces viral load to a nearly undetectable amount in infected patients after two days. But don't take my word for it. Here is the result of the third stage trials in the LANCET. I use Enovid (its name in Israel) and it appears to work. I have traveled, gone to crowded venues with poor ventilation, (although I still wear a mask) and eaten in restaurants, with no infection. There are no contraindications with any medication.. It is not a drug. Nevertheless The CDC and Health Canada have not authorized it. Israel, Germany, India and Singapore DID in 2021, and it's available in any drugstore in those countries. The additional tests by Health Canada and CDC should be expedited. It's even more inexcusable in Canada, since it was developed in Vancouver. https://www.thelancet.com/journals/lansea/article/PIIS2772-3682(22)00046-4/fulltext
SaNoTize are developing a nasal flu vaccine. They should receive funding.
My doctor recommended SaNoTize to me. I have used it for the last 6 months before and after any indoor activity (flight, haircut - still mask). When it comes to seeing friends or dining at restaurants, I opt for outdoors. So far, so good. (I’m also vaxed and boosted).
My husband (also vaxed and boosted) had Covid in May ‘22. I could not have been more exposed to him before he tested positive. I did get a funky sore throat (with lots of “raw egg white” saliva) but gargled aggressively with warm salt water 3x per day. I never tested positive (including 2 PCRs) despite my weird sore throat.
Did the salt water gargle prevent me from getting full blown covid? I have no idea. I’m also a swimmer (normal-high vitamin D, chlorine neti pot flip turns). I take a multi, vitamin C, zinc. Am I just following a bunch of quack witchcraft? Maybe. But at least I feel like I’m doing something.
Point is - it would be nice if we had a basic handle on some over-the-counter (SaNoTize) or home remedies that might prevent infection and/or lessen severity. The current vaccines aren’t enough! The FDA/CDC is reluctant to recommend anything additive because they fear it might cause one person not to vaccinate. Their only advice is “vaccine, vaccine, vaccine.” As a result, Americans are denied other reasonable options which could supplement vaccines. And Americans are increasingly saying “no, enough!” to the vaccine.
SaNoTize is not cheap. You can order it online and have it shipped from Israel. If enough Americans start importing it, the FDA will probably clamp down and prohibit it.
I had covid 19 in July 2022 and wish that i knew about Enovid at that time. It is a lot cheaper than getting sick and it probably costs pennies to make. Nitric oxide is the same substance given to premature babies, to kill viruses...it's not a novel substance; it's the spray bottle with the measured dose that makes it unique. There is no excuse not to approve it.
"The FDA/CDC is reluctant to recommend anything additive because they fear it might cause one person not to vaccinate. Their only advice is “vaccine, vaccine, vaccine.” This is not true.
"The FDA/CDC is reluctant to recommend anything additive because they fear it might cause one person not to vaccinate. Their only advice is “vaccine, vaccine, vaccine.” This is absolutely true! And it is a major problem.
They are also clearly more concerned about being blamed for any adverse results, than with taking that risk of blame to bring about the highly likely greater good of so many millions. That is never better illustrated than by the extended debate over the decision to ALLOW (not recommend) a six month vaccine for the elderly. That was a “no-brainer” but it invoked serious debate which shows the nature of the underlying predilections of the authorities. And the evidence would support an even more frequent vaccination for the elderly (50 million plus of us in the US). The only even mildly concerning hypothesis that would stand against more frequent vaxxing for seniors is the worry about OAS - a theory with very limited research and contradictory outcomes. But that fear of “safety” (however small the risk) - which dominates FDA and CDC decisions - is clearly what drives the thinking at those organizations. Never mind those of us at most risk of severe disease and death.
I've now had six vaccinations. I got sick after my first booster expired. I wish I had had the Enovid in July, 2022.
There is no excuse not to approve it. I will still get additional vaccinations, and the people who use it are more likely to get vaccinated!
I believe the most likely reason you didn't test positive is that you're female. I've noticed this pattern with most discordant male/female couples I know, where the male is the index case.
Actually, it IS a drug. It's also a treatment, not a vaccine. The study looks promising, but only reports data for seven days
A/O last October the NIH was soliciting volunteers for a clinical trial of SaNoTize in the USA. Given that the sponsor is also the manufacturer (as was the case for the Lancet study), some skepticism may be justified. But we'll see. If this proves effective, it looks like it could be a useful treatment, but treatments are substitutes for prophylactic measures, of course.
I wear masks in addition to taking the Enovid, and I have two bivalent vaccinations...but I was too scared to go to social gatherings or restaurants until I got the spray. Health Canada started its trials in July 2022, just after the Lancet report. I believe this works, and I have seen it work for a relative and a friend who both improved greatly after I sent them some of my very limited stock. That is enough proof for me.
I have been using Covixyl and Xlear. It boggles my mind that there is not more research being done.
Do you still mask indoors?
It depends. I still try to avoid large crowds. I do not mask at work, but I do mask in stores, doctors offices, etc.
When I read today’s YLE, my first thought was: SaNoTize!
My second thought was: You can’t post anything about a nasal spray that’s not approved by the FDA, because that’s MISINFORMATION.
But then I saw others had already posted about SaNoTize and joined them.
Yes, it’s mind boggling more research isn’t being done. People have a hunger for more tools to counter the virus, which can quickly land them in misinformation quicksand, even if the tool in fact works.
"You can’t post anything about a nasal spray that’s not approved by the FDA, because that’s MISINFORMATION." Rubbish. You just proved it's rubbish, in fact. You can post anything you want.
Having what you post treated seriously, on the other hand, is another story. Maybe it you did the necessary work to provide credible evidence for the things you post, they'd be treated with more respect.
🤣
Yes, and I am desperate to try anything that “might” work. I am reading more on SaNotize and might order. It is a shame that it will be cost prohibitive for many.
I pay the price. It costs 50 per cent less in Germany, but the Israeli firm is willing to ship worldwide. It's particularly galling because the scientist who invented it is Canadian/Israeli, and she went to Israel to manufacture it because she knew that it would take too long to get manufacturing up and running here. What happened to Canada?
To the best of my knowledge, I’ve never had Covid despite being exposed more than once. About 5 years ago, before the pandemic, I had two shingles shots and one MMR (I had such a such a strong reaction to MMR that I never went back for shot 2 - high fever for 3 days and nonstop sleep 14 days after shot).
Are the shingles and MMR vaccines from 5 years ago protecting me from covid? Maybe, but nobody seems to be studying this.
I also came to the comments today to share my experience with anti-viral nose sprays. I've been hoping for a post on these, but as mentioned by another commenter - they seem to risk falling into the 'misinformation' camp and so aren't talked about by many responsible COVID communicators. I have been using both Enovid and an iota-carrageenan spray for about a year now with good success. I am teacher in a primary school as is my husband and our two children attend the same school - so we have quite a bit of exposure!! During the winter and times of heavy transmission we all used the iota-carrageenan spray before school and Enovid after school. They both some decent studies with anti-viral success and seemed worth the try. We did not mask this year (though I do when working with actively sick kids and colleagues which happens a lot). We were sick significantly less than other students and staff. We also have travelled successfully (masking in airports/planes but not much elsewhere). We also managed one COVID case (picked up from a haircut in which my son forgot nose spray) without the rest of us getting sick (we did all use high-quality masks, lots of fresh air and isolation in addition to lots of nose spray).
For those in the EU, Enovid is now available through MaskWholesale.eu and is only 20 euros per bottle (still pricey but better than straight from the Sanotize website).
I think these need to be discussed more. What spray do you use? I have been using Xlear with my children. The company got into trouble for touting benefits of preventing Covid, but that does not surprise me.
While it isn’t a vaccine what do you think of Israel’s enovid as a precautionary measure?
It makes me a lot more confident when traveling, it appears to work for others (a relative and friend both benefited from it when very ill) and in my case, there was an extremely beneficial unintended side effect . It does what they say it does.
Thanks. We certainly need treatments that have proven to be effective as a supplement to preventative measures.
Yes, SaNoTize is the company, Enovid is the brand name of the nasal spray.
I really appreciate Dr. Jetelina’s and her colleague’s clear, fair-minded explanations. For me, this article is particularly helpful so as to have appropriate expectations: could be promising, but no magic bullet coming soon. This is just what I hope for and always get from Dr.Jetelina: clear, honest information, warts and all.
I see the discussion that has ensued here re Sanotize, all of which is new to me, and would be interested in any insight Dr. Jetelina and or her colleague can offer on that, as well.
Novavax may elicit mucosal immunity after 3rd shot- not sure why that isn’t discussed more often:
https://donford.substack.com/p/the-benefits-of-novavax-explained
I have two questions:
Does a nasal vaccine also protect mucosal membranes in the throat, in case COVID is breathed in through mouth?
If a nasal vaccine is a live virus, can someone who is just vaccinated infect another person?
The nasal vaccine does not protect you from anything that gets in via the mouth. I had a small stomach virus after I started taking Enovid regularly. Fortunately it was short lived, but I used Tums to cure it.
Great article. All the potential challenges and pitfalls notwithstanding, I wonder if any researchers are going to try simultaneous IM and Nasal vaccination? Might this spark an immune response like sending in the army and navy?
Some precedent for this upon quick search:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7812058/
Nicely done, as usual. Seems like something to really fund as benefits beyond Covid, and possibly unexpected, will likely result.
But why not target a more stable part of the virus? Why couldn’t a good pan corona vaccine essentially do what the mucosal is intended to do, either by dampening (if possible) transmission or by making infection useless, at least to the virus, from an evolutionary perspective. As in: “Change all ya like—it’ll do ya no good, as biophysics prevents you from changing this bit of structural whatnot we targeted.”
Let’s fund both/all!
Excellent material - Thank you
Thanks to all who comment. You provide me with ideas and opinions which I so much appreciate.
My dermatologist told me about Enovid, she buys it from the Israeli pharmacy online. Her family uses it. I’m not sure about the effectiveness of it, but it’s likely not harmful. Just expensive. A family member has started to use it.
Thank you for mentioning the Pan-coronavirus “super” vaccine at the bottom of this article; I had completely missed that one. Fascinating stuff!
Just got my 65+ extra injection! The pharmacist referred to it as a "booster," but I said I preferred to think of it as a "Big Boy's shot." :)
So I asked Microsoft Bing 'how to purchase SaNotize'.
There are numerous options and sources. Prices range between $170 and $250.
=======
Of interest is the pop-up on the site https://sanotize.com/faq/ that states:
IMPORTANT NOTICE
This website contains information about products that may not be available in all countries, or may be available under different trademarks, for different indications, or in different dosages. Nothing contained herein should be considered a solicitation, promotion or advertisement for any drug or medical device including the ones under development on this web site.
Any information on the products contained herein is not intended to provide medical advice nor should be used as a substitute for the advice provided by your physician or other healthcare provider.
======
There is some promotional/sales info here:
https://www.israelpharm.com/blog/newsweek-asks-why-the-fda-is-refusing-to-allow-use-of-nasal-sprays-as-a-barrier-against-covid-19/
The bottom link takes you to an article with a “Buy Enovid” link at the very bottom. The button appears to still work. If you’re willing to buy 10 nasal sprays, the price drops to $40 per bottle. Not a bargain, but cheaper than flying to Germany, Israel or India to stock up.
The article is worth a read - thanks for posting it. If officials encourage us to use hand sanitizer for our hands, why can’t we have a sanitizer for our nose?
Why can’t these types of tools be viewed as supplements to the vaccine, instead of as threats?
I agree. I had very reactogenic experiences after my second and third Moderna and can get no medical guidance on how to handle future vaccines other than “get the booster.” I have not received any other Covid vaccines because my experiences were so terrifying. So, I am trying anything and everything that seems low risk/high benefit. I cannot understand why they are not exploring less reactogenic vaccines, non MRNA options, other means of protection. It seems very black and white when there’s actually a lot of gray.
Bureaucrats can’t stand gray - it makes them nervous about being blamed for a decision. It has to be even more than just “beyond a shadow of a doubt”.
There was early research suggesting that using a steroid nasal spray reduced covid infection and symptoms. Any updates on that?
#6 - For live attenuated replication competent virus vaccines, there are two additional issues:
1. Risk/benefit at the individual level - depending on your circumstances deliberately exposing yourself to a pathogen may not be worth it
2. Risk/benefit at the population level - a live attenuated virus could mutate to something more virulent
Prime and Pull - has this been studied in the opposite direction - intranasal vaccine followed by parenteral booster? Intuitively, I would think this wouldn't work as well, but curious if it has actually been studied.