19 Comments

My husband is immunocompromised. He had no detectable antibodies after 2 doses of Moderna. He had a booster, but we aren’t confident it helped him much. A breakthrough infection for me could be fatal for him.

I have several autoimmune illnesses, and have had post-viral illnesses that last months to years. Already have POTS as a result of Ehlers Danlos Syndrome. Long Covid is a real possibility for me. Yes, we mask, everywhere, with n95s. Still, give me that shot. I will take it as soon as it becomes available.

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It seems we'd be so much better off with a third dose because we know for a fact that the first two were way too close together to be optimal. So we could just stop with 3. OTOH, what's wrong with a yearly shot? We do it for the flu.

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Breakthrough cases are no walk in the park, from what I've heard, and isn't there still a risk of developing long COVID? If getting boosters reduces the risk of breakthroughs isn't it worth it?

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I have not seen a study for this but I'm wondering if the colder storage conditions required by the Pfizer vaccine could have led to increased mishandling (not keeping cold enough ) of the vaccine thus making it less effective.

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Thank you so much for this information! Can I ask you about your opinion on Moderna vs. Pfizer for a 18-month old? I definitely see your points about Moderna's advantages. My only worry is that Moderna's dose may be too large for such a small child. Or do you think the benefits outweigh my concern? Put differently, if your girls were 18-months old, would you still pick Moderna for them?

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Is there any logic to “switching teams” for a booster shot? That is, if one was vaccinated with Pfizer originally, would there be benefits or drawbacks of a Moderna booster, or vice versa?

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What is the downside to getting a 3rd booster? Is there a health concern for why we shouldn't all get a 3rd booster? It seems to me that if it is available, and if it helps, why wouldn't we get it? What is the argument against it?

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We got three full dose moderna shots vs 2 full shots and the half/dose moderna booster. Two questions: is there any evidence given the full VDay half dose for the third shot when out immunity might wane. We are 75 second - what is the advantage if any of getting Pfizer for the next booster vs sticking with moderna?

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Thank you! Looking forward to this information. Also, I'm looking for info on mixing vaccines and timing of it, for someone who received 2 doses of Sinovac (it was what was available to them). They'll now be in the US and will be seeking a dose of one of the mRNA vaccines or J&J, and want to do so as informed as possible. I know the info on mixing and sinovac is limited. Any guidance or resources would be greatly appreciated.

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Katelyn, could you please explain the downside of getting a 3rd booster. If there's even a modest benefit, why not get it? Is it because there is a immune system "cost" whenever your body processes a vaccine? Or does the U.S. government not want to spend if it doesn't have to? And is there even a limit to how many vaccines you can get?!? Any clarity would be appreciated!

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